Better Brain Wiring Linked to Family Genes

 Better Brain Wiring Linked to Family Genes

 

"How well our brain functions is largely based on our family's genetic makeup, according to a University of Melbourne led study. The study published in The Journal of Neuroscience provides the first evidence of a genetic effect on how 'cost-efficient' our brain network wiring is, shedding light on some of the brain's make up.

..."The brain tries to maximize its bang-for-buck by striking a balance between making more connections to promote efficient communication and minimizing the "cost" or amount of wiring required to make these connections. Our findings indicate that this balance, called 'cost-efficiency', has a strong genetic basis."

..."Although genes play a major role in brain function, the environment and other factors contribute to when things go wrong in cases of mental illness and other brain disorders," he said.

...Across the entire brain, more than half (60%) of the differences between people could be explained by genes. Some of the strongest effects were observed for regions of the prefrontal cortex which play a vital role in planning, strategic thinking, decision-making and memory."

http://www.sciencedaily.com/releases/2011/03/110303111423.htm

 

I found a few snp's related to prefrontal cortex:

rs6465084 (GRM3) The A/A homozygotes (i.e., those with a genotype associ- ated with an increased risk for schizophrenia) had lower N-acetylaspartate/creatine levels in the dorsolateral pre- frontal cortex, possibly indicating decreased neuronal function.

http://ajp.psychiatryonline.org/cgi/reprint/163/4/740.pdf

 

rs1130233 A allele was associated with prefrontal region of AKT1-associated inefficient activation

https://www.jci.org/articles/view/34725

 

rs7794745 T allele linked with "disconnectedness" from the prefrontal cortex to areas of the brain related to language; autism risk allele.

http://www.sparkpeople.com/resource/health_news_detail.asp?health_day=645382

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As for me, I have:

 

rs6465084: AA ( had lower N-acetylaspartate/creatine levels in the dorsolateral pre- frontal cortex, possibly indicating decreased neuronal function.

rs1130233: CC ( prefrontal region of AKT1-associated inefficient activation)

rs779745: AT ("disconnectedness" from the prefrontal cortex to areas of the brain related to language; autism risk allele.)

 

 

I am not normally neurologically wired. Who decides what's better neurologically wired? I know that I have a different type of mind, but it's not deficient.

 

I am a neurodivergent with Dyslexia,Dyspraxia,ADHD.  Those neurodivergent conditions have symptoms/traits that overlap with those of autistic spectrum. Now my mother and I believe that my father had a form of autism even though he had a diagnosis of paranoid schizophrenia.

 

I was misdiagnosed as having schizoaffective bipolar disorder because of my neurodivergent-related cluttering speech which is the type of speech that my mom told me that my father actually had along with stuttering.

 

BTW The symptoms of neurodivergence overlap with those of schizophrenia.

Many of the traits of disorganized type of schizophrenia fit with Dyspraxia which is aka Developmental Coordination Disorder. It used to be called Clumsy Child Syndrome. It has symptoms/traits that overlap with Dyslexia, ADHD,and Autistic Spectrum.

 

any way.....it seems that I have additional things that point to my being a genetic neurodivergent.


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