Neurodivergence

  This is a blog post about rare Nonsense Mediated Decay-escaping stop gained variants. A stop-gained variant, also known as a nonsense mutation, is a type of genetic change where a single nucleotide substitution introduces a premature termination codon (PTC) within the coding sequence of a gene. This leads to early termination of translation, producing a truncated protein. Depending on the location of the PTC and the structure of the affected transcript, the variant may trigger nonsense-mediated decay (NMD) or escape it, making the biological impact isoform-specific and context-dependent. Nonsense-mediated decay–escaping (NMD-escaping) describes a situation where a transcript containing a premature termination codon (PTC) avoids degradation by the cell’s NMD pathway and remains stable enough to be translated. While NMD typically prevents the production of truncated proteins by degrading transcripts with early stop codons, escape occurs when the PTC is located in the last exon or w...

  This is a blog post about my results from VO2max Testing (Discontinuous Protocol) that I did at Washington State University in Pullman.  It includes both VO2max Testing and checking blood lactate concentrations.  I've been wanting to get to the bottom of my unusual high speed exercise endurance for a long time.  I even wondered if there is a connection to my ADHD which I have viewed as a great reservoir of energy that prevents me from being tired when doing cardiovascular activity. Cardiovascular exercise makes me more energetic instead of tired.   Wanting to help bring insight into the energy levels of people that have ADHD was another reason why I did the VO2max testing. I experience an unusual lack of fatigue during high-speed cardiovascular activity such as rapid cycling on an indoor exercise bike, running in place, and speedpunching. Despite engaging in 1-hour high-intensity cardio workouts daily , I did not feel any cardiovascular tiredness.  I...

  This is a blog post about ChatGPT Comprehensive Analysis of my workout performance and my interest in VO2 Max and Lactate Assessment.  It is the result of Fitness/Exercise/Diet which is one of the ChatGPT projects that I created. ChatGPT and I have been discussing about my high intensity cardio workouts on a regular basis.  They have also been discussed in relation to my neurodivergence (Dyslexia, Dyspraxia, ADHD) and Ataxia. Discussion includes possible genetic factors which have been gone over in in much depth in my Genomics/Genetics ChatGPT project.  I have an unusual high speed exercise endurance for a 53 year old man.  I can exercise in anaerobic and VO2 max zone for long periods of time.  I don't get tired from high speed cardiovascular activity, and so I am able to move very rapidly and burn calories with ease.   Of course, this greatly helps me get into caloric deficit  which leads to fat loss and getting leaner.   I don't...

                     Potential ADHD Genes Based On Ma'ayan Lab's ARCHS4 Data - Assistance From ChatGPT   Introduction to Gene Information for ADHD Attention-Deficit/Hyperactivity Disorder (ADHD) is a complex neurodevelopmental condition influenced by a combination of genetic, environmental, and neurological factors. Recent advancements in genomics have enabled researchers to identify specific genes and pathways that may contribute to the symptoms and traits associated with ADHD, such as inattention, impulsivity, and emotional dysregulation. This blog post explores detailed information about key ADHD-related genes derived from the ARCHS4 database, which provides insights into gene expression, biological processes, pathways, and tissue-specific activity. By analyzing this data, we can better understand how these genes influence neural and behavioral functions, shedding light on the biological underpinnings of ADHD. The genes exam...