Neurodivergence

  This is a blog post about my variants in old Dyslexia-linked genes.    With my being a neurodivergent (having Dyslexia, Dyspraxia, ADHD) with Ataxia, I was very curious about genes associated with Dyslexia.  This concludes my Developmental Neurogenomics series of blog posts.  My Neurological Makeup includes both Neurodivergence and Ataxia https://neurodivergence.blogspot.com/2024/01/my-neurological-makeup-includes-both.html The DRD4 (Dopamine Receptor D4) Gene https://neurodivergence.blogspot.com/2024/01/the-drd4-dopamine-receptor-d4-gene.html My Potential Dyslexia Risk Factors Based On 2022 Published 'Discovery of 42 genome-wide significant loci associated with dyslexia' https://neurodivergence.blogspot.com/2024/02/my-potential-dyslexia-risk-factors.html My Potential ADHD Risk Factors based on 2022 Published 'Genome-wide analyses of ADHD identify 27 risk loci' https://neurodivergence.blogspot.com/2024/03/my-potential-adhd-risk-factors-based-on.html My Potenti...

  I learned that my Attention Deficit Hyperactivity Disorder (ADHD) is in connection to variants in Adhesion G Protein-Coupled Receptor genes.  I have three rare Upstream single nucleotide variants in Promoter region in Adhesion G Protein-Coupled Receptor L1 (ADGRL1) aka Latrophilin1 (LPHN1).  I have one rare Missense variant, one rare 3 Prime Untranslated Region (3'UTR) single nucleotide variant, two uncommon 5 Prime Untranslated Region (5'UTR) single nucleotide variant in Promoter region and one uncommon 3'UTR single nucleotide variant in Adhesion G Protein-Coupled Receptor L3 (ADGRL3) aka Latrophilin3 (LPHN3). All eight single nucleotide variants have disease-threshold allele frequencies less than the 5% frequency which is the maximum disease-threshold allele frequency that I use for Attention Deficit Hyperactivity Disorder. All have Combined Annotation Dependent Depletion (CADD) scores of at least 10 which means that they are predicted to be in top 10% of most deleter...